Patient Develops Stevens-Johnson Syndrome in Rehabilitation Facility
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Case Overview
This case takes place in Maryland and involves a male patient who developed Stevens-Johnson syndrome, which eventually progressed to toxic epidermal necrosis, after being given a mixture of antibiotics and anti-seizure medication. The patient was originally admitted to the hospital after he suffered a brain aneurysm that nearly proved fatal. While recovering, he was given a mixture of amoxicillin and dilantin, the latter of which is an anti-epileptic drug used to control seizures. After a brief stay in the hospital, the man was transferred to an in-patient rehabilitation facility, where the medication was continued. Shortly after arriving at the facility, the man developed a severe rash that spread rapidly across his abdomen, arms, neck, and face. Multiple individuals at the facility noted the patient’s worsening condition, however the only treatment that was attempted was topical hydrocortisone. After suffering for nearly two weeks, employees of the rehabilitation facility noted that the patient’s skin had begun to peel off, at which point he was finally transferred to the hospital. The patient was diagnosed with toxic epidermal necrosis (TEN stemming from his dilantin almost immediately upon arrival. It is alleged that the patient suffered massive injuries due to the delay in care he received while staying at the rehabilitation center.
Questions to the Dermatology expert and their responses
Do you have extensive experience diagnosing/treating patients with TEN/SJS?
My specific area of expertise is in blistering diseases of skin and mucous membranes, and my primary diseases of interest are autoimmune causes such as pemphigus and pemphigoid. That being said, I have worked at one of the nation's most prestigious medical centers for 30 years, and I regularly diagnose patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), and consult on treatment options for these patients.
What steps and protocols should be taken after patient starts showing signs of skin reaction to medication?
The drug should be stopped at the first sign of developing SJS, which is the time at which blistering of the skin or mucous membranes is observed without another probable cause. In addition to stopping the offending medication, the patient should be sent to a specialized unit, usually a burn unit, for supportive care.
At what point should medication be changed or discontinued?
The drug should be stopped at the first sign of developing SJS, which is the time at which blistering of the skin or mucous membranes is observed without another probable cause.
About the expert
This highly qualified and double board certified dermatologist regularly treats patients with Pyoderma Gangrenosum. He is double board certified in dermatology and dermatologic immunology. This expert completed residency training in dermatology and fellowship training in immunodermatology at the University of Michigan. He is a member of several professional organizations including the American Academy of Dermatology, American Dermatologic Association, and American Society for Clinical Investigation. He has authored 200+ articles in peer reviewed journals and is a frequently invited guest speaker at major conferences in the field. Currently, this expert is the Director of the Dermatologic Laboratory and a Professor of and Pathology at a top ranking university and an attending dermatologist at a university affiliated hospital.

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About the author
Joseph O'Neill
Joe has extensive experience in online journalism and technical writing across a range of legal topics, including personal injury, meidcal malpractice, mass torts, consumer litigation, commercial litigation, and more. Joe spent close to six years working at Expert Institute, finishing up his role here as Director of Marketing. He has considerable knowledge across an array of legal topics pertaining to expert witnesses. Currently, Joe servces as Owner and Demand Generation Consultant at LightSail Consulting.
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