This case involves a male patient who had developed a bone void secondary to a broken leg suffered while skiing. In order to treat this void, the patient received an injection of bone substitute. The procedure was performed without evident complications and the material was placed in the proper location. Nevertheless, the patient experienced severe pain over the next day. X-rays appeared to indicate that some of the material had seeped out of the implantation site. The patient returned to his orthopedic surgeon who said that the placement looked normal and that the pain would subside naturally. Further testing by other medical professionals revealed that the bone substitute was impinging on a major nerve bundle, causing permanent damage that would likely produce ongoing pain.