Infectious disease expert witness advises on sepsis fatality that lead to wrongful death action

    Infectious disease expert witness advises on sepsisAn infectious disease expert witness advises on a case involving a patient who died from sepsis. Decedent was treated in the defendant emergency room for a left swollen arm/hand/wrist with pain, generalized weakness, unsteadiness, some shortness of breath, and loss of appetite. He was diagnosed acute gout and discharged. Less than 2-days later, he was taken to another emergency room, where he was diagnosed with sepsis due to strep pneumonia, was intubated, and admitted to intensive care. His condition deteriorated and he died a week later.

    The cause of death is listed as refractory asystolic cardiac arrest 5 minute duration, hemorrhagic myocardial infection one week duration, and pneumococcal infection/sepsis two week duration.

    Decadent’s family filed a negligence action against the defendant emergency room in the Pennsylvania Court of Common Pleas.

    Question(s) For Expert Witness

    • 1. Would the patient have had a better outcome if he had been treated for sepsis during his initial emergency visit?
    • 2. What else contributed to his death?

    Expert Witness Response

    It is essential to emphasize the likelihood of severe morbidity and mortality at the time of the initial presentation of the patient when he presented with septic arthritis. He was found to be bacteremic with S. pneumoniae and so the question arises, what was the pathogenesis of the septic arthritis? It is unequivocal that septic arthritis involving S. pneumoniae is the result of bacteremia and may in turn have contributed to the perpetuation of the bacteremia. In other words, patient had been bacteremic prior to the initial presentation in the emergency department and the bacteremia is almost certainly the result of primary respiratory infection which was apparent but not diagnosed at the initial presentation. S. pneumoniae resides in the upper respiratory tract and generally causes pneumonia, which I believed the patient had at the time of the initial presentation.

    He certainly had an abnormal chest CT scan when he was admitted later. Moreover, he never died from the septic arthritis, the critical factor which contributed to the patient’s death was infective endocarditis with a devastating aortic valve infection. In all likelihood, this infection was also the result of the primary bacteremia secondary to the respiratory tract infection and it is more than likely that at the time of his first presentation with septic arthritis, that he already had cardiac valve involvement which progressed rapidly to cause his demise.

    He almost certainly suffered from Austrian’s syndrome which is a triad of S. pneumoniae causing pneumonia, infective endocarditis, and meningitis. He had all three and therefore fits this diagnosis perfectly. The implication of this understanding, is that even if he had received high dose antibiotic therapy at the time of his initial presentation to the ED, (where the diagnosis of septic arthritis was missed) that he already had bacterial dissemination to other sites and that one could not state with greater than 50% probability that he would have survived had he been given high dose IV antibiotics at the time. He had a high mortality syndrome at his initial presentation.

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