This case involves a twenty-three-year-old female patient who was seen in the emergency room for lower back pain after being involved in a car accident. The patient was started on an IV drip of normal saline by an ER nurse while she waited for the ER physician to examine her. When the physician arrived forty-five minutes later, the patient complained of severe pain and tightness around the site of the IV. The patient’s arm displayed local edema, skin blanching, skin coolness, severe pain, and leakage at the puncture site. It was determined that the patient sustained IV infiltration burns and had to undergo surgical decompression of the forearm to relieve the rapid pressure buildup in the subcutaneous tissue.