This case involves a male patient in his late 40s with a past medical history significant for ulcerative colitis, for which the man had been taking immunosuppressive drugs under the supervision of his gastroenterologist. The patient presented to his primary care physician complaining of pain and discomfort in his perianal area, which was diagnosed as an infected hair follicle. The man was given a topical cream without instructions for further follow up. A few days later, the patient presented to the emergency room with complaints of a fever and increasing pain. Labs were performed and the man was discharged with a diagnosis of a likely viral infection. The next day the man returned to the hospital with worsening fever, pain, and weakness. He was admitted and diagnosed with sepsis. Despite treatment the man was forced to undergo multiple amputations due to a systemic staph infection.