The patient presented to her primary care physician complaining of atypical chest pain. The treating physician ordered investigation and it was determined that the dissection was growing and most likely responsible for the new onset pain. After an extended workup it was decided that the patient required an open repair of the descending aortic aneurysm. The patient was taken to surgery and the procedure was conducted under hypothermic circulatory arrest with cardiopulmonary bypass through right leg and spinal cord drainage. The surgery was successful and was not met with any complication. In the post-operative period the patient complained of right leg pain at which point a vascular consult was requested. The vascular surgeon diagnosed the patient with compartment syndrome of the right lower limb. The patient required a fasciotomy to relieve the rapidly increasing pressure which was causing her causing excruciating pain. There were also concordant lab value arrangements including increasing creatinine levels and a severely elevated CK. The patient suffered from rhabdomyolysis that went undiagnosed and untreated for some time. When the condition was finally recognized it had progressed rapidly and there was no longer anything that could be done salvage the limb. The patient underwent a below-the-knew amputation of the right limb to prevent further advancement of the condition.