This case involves a male who underwent a procedure to remove a soft tissue sarcoma from the retroperitoneal region. The procedure was noted to be a success and was conducted without incident. Approximately twenty-four to forty-eight hours after the surgery, however, the patient started to develop signs and symptoms consistent with sepsis. A second procedure revealed that there were two puncture holes that perforated the colon and a delay to identify and repair these injuries allowed the patient to deteriorate rapidly. The patient was in the intensive care unit but died one month later after fighting the severe infection and its effects on the other body organs.