This case involves a fifty-nine-year-old male patient who presented to the hospital with complaints of chest pain, shortness of breath, and a persistent cough. The patient had been a chronic smoker but had quit due to respiratory trouble. A suspicious spot on the chest imaging along with the presenting symptoms prompted physicians to order a lung biopsy. A CT-guided biopsy was performed using a posterior approach and there were no immediate complications in the PACU. Three core samples were taken and the pathologist provided a pathology report that diagnosed a poorly differentiated squamous cell carcinoma. Shortly after the procedure, the patient developed shortness of breath and a severely increased heart rate. He was transferred to ICU and immediately upon arrival, he went into cardiopulmonary arrest. ACLS maneuvers were initiated while a chest tube was placed that returned 3000cc of dark red blood. Three units of emergency blood were administered during the code, but the patient died soon thereafter.