Phenergan Toxicity Allegedly Causes Cardiac Arrest and Death

ByMichael Talve, CEO

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Updated onJanuary 10, 2022

Phenergan Toxicity Allegedly Causes Cardiac Arrest and Death

This case involves a twenty-seven-year-old patient that presented to the emergency department complaining of nausea, diarrhea, and vomiting associated with a severe cough. He was treated with Promethazine, Dilaudid, Zofran, Ultram, Pantoprazole, Fentanyl, and Phenergan. Additionally, he was given a prescription for Phenergan upon discharge from the emergency room. The patient returned to the emergency room two days later with the same complaints. He was treated with Hydromorphone, Prochlorperazine, and Pantoprazole. Once again, he was discharged without an extensive workup to rule out life-threatening cardiac or respiratory disease. Three days after the final discharge, the patient was found dead in his home. Contributing factors to his death included the lethal combination of Phenergan, Hydrocodone, and Diphenhydramine.

Question(s) For Expert Witness

1. What can be done to avoid drug-drug interactions and overdoses in cases like this one?

Expert Witness Response E-005297

inline imageThis patient was inappropriately managed on several accounts:

inline image1) A thorough work up for abdominal pain, assumed to have been an issue given initial treatment with Dilaudud, Ultram, and Fentanyl, should have been done at the initial admission, including cardiovascular imaging studies and a gastroenterology consult. If this was not done on initial admission it should have absolutely been done on the subsequent admission within one day from previous discharge.

inline image2) The medication management for this patient was not reflective of the standard of care. I cannot understand how all of these medications could be prescribed for a patient given the presenting symptoms and multiple admissions without an appropriate and relevant diagnosis

inline image3) The multiple discharges for this patient are not reasonable without a diagnosis and final treatment plan. The patient should have been kept longer and evaluated further.

About the author

Michael Talve, CEO

Michael Talve, CEO

Michael Talve stands at the forefront of legal innovation as the CEO and Managing Director of Expert Institute. Under his leadership, the Expert Institute has established itself as a vital player in the legal technology arena, revolutionizing how lawyers connect with world-class experts and access advanced legal technology. Michael's role involves not only steering the company's strategic direction but also ensuring the delivery of unparalleled intelligence and cutting-edge solutions to legal professionals. His work at Expert Institute has been instrumental in enhancing the capabilities of attorneys in case preparation and execution, making a significant impact on the legal industry's approach to expert consultation and technological integration. Michael's vision and execution have positioned the Expert Institute as a key facilitator in the intersection of law and technology.

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