This case involves a nine-year-old female patient with a medical history significant for leukemia and was undergoing chemotherapy with methotrexate. The patient underwent a lumbar puncture that was met with several complications including a subdural hematoma with compression of the cauda equina and severe spinal hemorrhage. The patient had the lumbar puncture despite her coagulopathic status and was given platelets as the only precaution. A few hours after the LP, the patient could not move her lower extremities and she became incontinent. The patient was then rushed to the OR for an emergency decompression, but a poor prognosis was discussed with the parents given the patient’s refractory leukemia, coagulopathy status, and spinal instability. The patient survived the procedure but suffered from complications for four months before passing away.