This case involves a 52-year-old man who was being treated for a subacute sinus infection. During that period he was taking a combination of medications, including Avelox. The patient was diagnosed with a viral infection after a nasal endoscopy showed no evidence of bacterial sinusitis. His doctor prescribed medication to treat the inflammation over a period of 6 days and after which concluded his treatment. The doctor did not advise the patient about reactions or contraindications to the medications, especially Avelox. Shortly thereafter the patient began to take his regular early morning jogs, but started to experience pain in his calf. He was evaluated by an orthopedic who noticed strain in his calf muscle which tore less than a week later.