This case involves a thirty-seven-year-old female who died of sepsis while being hospitalized for a skin infection. The woman presented to the emergency department with a red inflamed skin lesion on her leg which was diagnosed as cellulitis. Although antibiotics were initiated, the woman started to feel extremely ill. She began to experience a high fever accompanied by rapid breathing, confusion, and lower extremity swelling. They administered aspirin and a higher dose of antibiotics in an attempt to treat her condition. Forty-five minutes later, she developed severe hypotension and tachycardia which resulted in a loss of consciousness. A pulse could not be palpated on her. She was successfully resuscitated but lapsed into a coma thirty minutes later. The next day, the physician notified her family that she required life support and would not survive without it. The family decided to withdraw life support and the woman died shortly thereafter.