This case involves a sixteen-year-old male who presented to the ER with fever, cough, shortness of breath, and intense chest pain. The boy’s past medical history included sickle cell anemia and recurrent infections. An x-ray was performed and he was diagnosed with pneumonia. Antibiotics and intravenous fluids were administered to him for a day. The next day the patient’s oxygen saturation declined to 65% and he still experienced fever and chest pain. He was given pain medications and received continuous positive airway pressure (CPAP). His oxygenation level continued to decline until he lapsed into a coma. After being resuscitated for twenty minutes, the boy regained consciousness. Once stabilized, it was evident that he sustained brain injuries as a result of oxygen deprivation. He was discharged once he was able to breathe independently. The months following hospitalization, the boy was unable to perform rudimentary tasks such as feeding and dressing himself, and formulating clear sentences. His teacher reported that his reading and writing level was at a third-grade level and he was unable to keep up with his peers. He required homeschooling, occupational therapy, and physical therapy. His pediatrician noted that he believed the boy experienced acute chest syndrome. This diagnosis was not made by the ER.